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Title   췌장암 및 담도암에서 담즙정체 해소전후의 혈청 CA 19-9 치의 변화 ( The Significance of Serum CA 19-9 Level Change after Biliary Drainage Procedures in Pancreatic and Biliary Tract Cancer )
Publicationinfo   1995 Jan; 027(06): 929-936.
Key_word   Tumor marker, CA 19-9, Biliary drainage, Pancreatic cancer, Biliary tract cancer
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Abstract   Although CA 19-9 has been widely used as a tumor marker for the diagnosis of pancreatobiliary cancers, the pattern of CA l9-9 level change after biliary drainage has not been well characterized. Because biliary drainage procedures are frequently employed for the temporary or palliative measures in biliary obstruction, the precise understanding on the change of CA 19-9 level after biliary drainage may be very helpful for the follow-up evaluation of those cases. We prospectively analyzed the serum CA 19-9 level before and after percutaeous transhepatic biliary drainage (PTBD) and biliary stent in patients with pancreatic, biliary tract cancer and common bile duct stone. Serum CA 19-9 level was initially measured by radioimmunoassay in 69 patients with be nign and malignant pancreatobiliary diseases. In 22 of 69 patients, PTBD and/or the insertion of biliary stent were performed and serial checks of CA 19-9 levels were followed. The elevation of serum CA 19-9 level was highly associated with pancreatobiliary cancers, especially in the cases with biliary obstruction, and in the CBD stones complicated with acute cholangitis. The serum CA 19-9 levels in most cases were significantly decreased by PTBD. There was the trend that the decrease after PTBD in biliary tract cancer was more prominent than that of pancreatic cancer. The elevation of serum CA 19-9 level was highly associated with the presence of biliary obstruction in pancreatobiliary cancers. Because the biliary drainage procedures significantly decrease serum CA 19-9 level, this can not be used for the marker of cancer pragression after biliary drainage procedures.
저 자   김현각(Hyun Kag Kim),이창희(Chang Hee Lee),류백렬(Baek Yeol Ryoo),정숙향(Sook Hyang Jung),김유철(You Cheoul Kim),김창민(Chang Min Kim),이진오(Jhin Oh Lee),강태웅(Taik Koo Yun),도영수(Young Soo Do),이병희(Byung Hee Lee)